1. Mental Clarity
Black seed's power in improving mental clarity in people of all ages has been proven in a number of clinical studies.
A 2013 human study in the Journal of Ethnopharmacology found a “significant difference” in mental acuity and logical memory of 40 elderly volunteers after nine weeks on black seed capsules, and a 2018 study in Human and Experimental Toxicology seemed to indicate that black seed could ward off the symptoms of Alzheimer’s disease. This study, which was carried out on rats, found that thymoquinone improved cognitive decline and reduced inflammation, thus pointing to possible therapeutic benefits for Alzheimer’s patients.
Effects on mental clarity were also proven in a study on adolescent males; the 2014study found that black seed improved cognition and mood and decreased anxiety, after previous studies found anti-anxiety, anti-depressant, and anti-fatigue effects in mice.
2. Metabolic Disease
Metabolic disease is characterized by a cluster of metabolic disorders obesity, hyperglycemia, and hypertension. Highly prevalent in modern society, particularly as linked to the Standard American Diet, metabolic disease can lead to diabetes and heart failure.
Black seed's power, with regard to staving off the symptoms of metabolic disease, has been proven in several studies. In one recent article in the Journal of Endrocrinology and Metabolism, researchers from the Indian Council of Medical Research showed that black seed improves glucose tolerance as efficiently as metformin, the most common oral antidiabetic drug used in the treatment of type 2 diabetes. A 2014 study in Pharmaceutical Biology found that black seed may have beneficial effects in treating dyslipidemia and coronary heart disease, two conditions linked to metabolic syndrome.
A recent study in rats – the first of its kind – found that thymoquinone could also be used to reduce the symptoms of type-2 diabetes, “significantly” decreasing blood glucose levels and improving the lipid profile of diabetic rats, and a 2015 study published in the Journal of Cardiovascular Pharmacology found that the coadministration of black seeds and turmeric to fructose-fed rats was effective in preventing hypertension, hyperglycemia, and other problems associated with metabolic disease.
While these findings are promising, a recent human study in hypertensive elderly patients found that while a trend towards a slight decrease in blood pressure was found, the effectiveness of black seed in treating hypertension could not be definitively proven.
3. Liver Disease
Studies show that black seed can be beneficial for people suffering from liver disease or damage.
A 2018 study in the International Journal of Preventive Medicine found that thymoquinone significantly enhanced the ability of mouse livers to resist morphine toxicity thanks to the herb's powerful antioxidant effects; and a 2017 study in rats found that black seed oil could enhance the renal protection mechanism, thus reducing complications and progression of liver disease.
While this research is certainly promising, more work is needed to fully understand this health benefit of black seeds.
4. Asthma and Lung Health
A good deal of research has been carried out with regards to the anti-inflammatory effects of black seed oil, particularly as linked to asthma and other respiratory problems. A 2018 study found that thymoquinone's anti-inflammatory properties can help mediate asthma symptoms, and a 2007 study on asthmatic adults found that boiled black seed could reduce severity and frequency of asthma symptoms.
Another 2018 study, published in Alternative Therapies in Health and Medicine, found that black seed was a promising antitussive or cough suppressant, and an ongoing study on the effects of black seed oil for asthma and allergies proved promising in phase one and has since moved into human trials.
5. Chronic Pain
Black seed’s anti-inflammatory effects may also help sufferers of chronic pain, particularly pain linked to peroxynitrite, such as chronicfatigue syndrome, myalgic encephalomyelitis, and fibromyalgia. One 2018 study found that TQ significantly inhibited peroxynitrite-induced oxidative damage, and researchers concluded that black seed could be an important tool in the development of strategies to treat or manage these pain disorders.